Suran Nethisinghe Selected Research

Spastic ataxia Charlevoix-Saguenay type

11/2022	Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.
10/2021	Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS.
1/2018	Optical coherence tomography in autosomal recessive spastic ataxia of Charlevoix-Saguenay.
1/2017	Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin.
1/2016	A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay.
1/2013	The ARSACS phenotype can include supranuclear gaze palsy and skin lipofuscin deposits.

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Suran Nethisinghe Research Topics

Disease

6	Spastic ataxia Charlevoix-Saguenay type 11/2022 - 01/2013
5	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 01/2013
4	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 07/2022 - 01/2013
3	Ataxia (Dyssynergia) 11/2022 - 01/2017
1	Friedreich Ataxia (Friedreich's Ataxia) 01/2023
1	Cerebellar Ataxia (Dysmetria) 11/2022
1	Huntington Disease (Huntington's Disease) 07/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2021
1	Motor Neuron Disease (Primary Lateral Sclerosis) 02/2014
1	Muscular Atrophy (Muscle Atrophy) 02/2014
1	Paralysis (Palsy) 01/2013

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2016
3	polyglutamineIBA 07/2022 - 01/2013
2	FrataxinIBA 01/2023 - 07/2021
2	VimentinIBA 10/2021 - 01/2017
1	IntegrinsIBA 11/2022
1	tributyl phosphate (TBP)IBA 01/2018
1	Adenine FDA LinkGeneric 01/2018
1	CytosineIBA 01/2018
1	GuanineIBA 01/2018
1	Retinaldehyde (Retinal)IBA 01/2018
1	TATA-Box Binding Protein (TATA-Binding Protein)IBA 01/2018
1	UbiquitinIBA 01/2017
1	Androgen Receptors (Androgen Receptor)IBA 02/2014
1	LipofuscinIBA 01/2013

Therapy/Procedure

1	Therapeutics 10/2021